Complex 8vpk
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 2.63 |
| System mass | 1537.48 kDa |
| Deposition year | 2024 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Mycolicibacterium |
| RCSB PDB Entry | 8vpk |
| Reference | Majumdar Soneya, Kashyap Amuliya, Koripella Ravi K., Sharma Manjuli R., Hurst-Hess Kelley, Manjari Swati R., Banavali Nilesh K., Ghosh Pallavi, Agrawal Rajendra K.. 2025. HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria Proceedings of the National Academy of Sciences |
| Equivalence Class |
NR_all_76090.17
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | ERY |
| Residue | . / 3201 |
| Chain | KA / A |
| Non-redundant | True |
| Interacting RNA chains | D/A |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | D/A: rRNA |
| RNA family global | rRNA |
| Volume | 347.12 Å3 |
| Hydrophobicity | 0.117 |
| Hydrophilicity | 1.371 |
| Buriedness | 0.830 |
| Don/acc character | 1.758 |
| SiteScore | 1.153 |
| D Score | 0.881 |
| Kd | — |