Complex 8uvs
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.75 |
| System mass | 4572.87 kDa |
| Deposition year | 2023 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Thermus |
| RCSB PDB Entry | 8uvs |
| Reference | Phelps Gregory A., Cheramie Martin N., Fernando Dinesh M., Selchow Petra, Meyer Christopher J., Waidyarachchi Samanthi L., Dharuman Suresh, Liu Jiuyu, Meuli Michael, Molin Michael Dal, Killam Benjamin Y., Murphy Patricia A., Reeve Stephanie M., Wilt Laura A., Anderson Shelby M., Yang Lei, Lee Robin B., Temrikar Zaid H., Lukka Pradeep B., Meibohm Bernd, Polikanov Yury S., Hobbie Sven N., Böttger Erik C., Sander Peter, Lee Richard E.. 2024. Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus Proceedings of the National Academy of Sciences |
| Equivalence Class |
NR_all_65795.87
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | Y7K |
| Residue | . / 1842 |
| Chain | YLB / 1a |
| Non-redundant | True |
| Interacting RNA chains | FA/1a |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | FA/1a: rRNA |
| RNA family global | rRNA |
| Volume | 408.51 Å3 |
| Hydrophobicity | 0.184 |
| Hydrophilicity | 1.107 |
| Buriedness | 0.702 |
| Don/acc character | 1.926 |
| SiteScore | 1.153 |
| D Score | 1.000 |
| Kd | — |
| Compound | Y7K |
| Residue | . / 1841 |
| Chain | JID / 2a |
| Non-redundant | True |
| Interacting RNA chains | JC/2a |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | JC/2a: rRNA |
| RNA family global | rRNA |
| Volume | 341.63 Å3 |
| Hydrophobicity | 0.226 |
| Hydrophilicity | 1.120 |
| Buriedness | 0.704 |
| Don/acc character | 2.290 |
| SiteScore | 1.154 |
| D Score | 0.997 |
| Kd | — |