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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 8ut0

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.22
System mass 3172.44 kDa
Deposition year 2023
Molecule type RNA/Protein
# RNA entities 1
Organism Saccharomyces
RCSB PDB Entry 8ut0
Reference Musalgaonkar Sharmishtha, Yelland James N., Chitale Ruta, Rao Shilpa, Ozadam Hakan, Taylor David W., Cenik Can, Johnson Arlen W.. 2025. The assembly factor Reh1 is released from the ribosome during its initial round of translation Nature Communications
Equivalence Class NR_all_90506.85
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 3HE
Residue . / 3401
Chain GC / A
Non-redundant True
Interacting RNA chains IA/A
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains IA/A: rRNA
RNA family global rRNA
Volume 270.28 Å3
Hydrophobicity 0.299
Hydrophilicity 0.812
Buriedness 0.598
Don/acc character 1.629
SiteScore 0.807
D Score 0.816
Kd