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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 8qk7

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.77
System mass 2253.85 kDa
Deposition year 2023
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 8qk7
Equivalence Class NR_all_35542.167, NR_all_83717.187
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 3216
Chain MO / 1
Non-redundant True
Interacting RNA chains X/1
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains X/1: rRNA
RNA family global rRNA
Volume 248.68 Å3
Hydrophobicity 0.178
Hydrophilicity 1.111
Buriedness 0.716
Don/acc character 0.953
SiteScore 1.029
D Score 0.837
Kd

Compound SPM
Residue . / 3349
Chain PT / 1
Non-redundant True
Interacting RNA chains X/1, W/5
RNA environment detailled ion
RNA environment global RNA
RNA family chains W/5: tRNA, X/1: rRNA
RNA family global multiple
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd