HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Complex 8fc5

System information

Experimental technique X-ray
Experimental resolution 2.65
System mass 4427.72 kDa
Deposition year 2022
Molecule type RNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 8fc5
Reference Chen Chih-Wei, Leimer Nadja, Syroegin Egor A., Dunand Clémence, Bulman Zackery P., Lewis Kim, Polikanov Yury S., Svetlov Maxim S.. . Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A Nature Communications

Compound ARG
Residue . / 230
Chain ZRA / 1B
Non-redundant True
Interacting RNA chains B/1B
Volume 218.83 Å3
Hydrophobicity 0.015
Hydrophilicity 1.851
Buriedness 0.576
Don/acc character 1.070
SiteScore 1.042
D Score 0.649

Compound ARG
Residue . / 319
Chain UTA / 1F
Non-redundant True
Interacting RNA chains A/1A
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -

Compound HGR
Residue . / 4032
Chain TQA / 1A
Non-redundant True
Interacting RNA chains A/1A
Volume 498.38 Å3
Hydrophobicity 1.017
Hydrophilicity 0.939
Buriedness 0.801
Don/acc character 0.852
SiteScore 1.238
D Score 1.114

Compound HGR
Residue . / 3712
Chain SKC / 2A
Non-redundant True
Interacting RNA chains BB/2A
Volume 507.30 Å3
Hydrophobicity 0.834
Hydrophilicity 1.407
Buriedness 0.773
Don/acc character 0.540
SiteScore 1.200
D Score 0.945

Compound ZIT
Residue . / 4033
Chain UQA / 1A
Non-redundant True
Interacting RNA chains A/1A
Volume 370.78 Å3
Hydrophobicity 0.319
Hydrophilicity 0.994
Buriedness 0.729
Don/acc character 0.791
SiteScore 1.142
D Score 1.005

Compound ZIT
Residue . / 3713
Chain TKC / 2A
Non-redundant True
Interacting RNA chains BB/2A
Volume 350.55 Å3
Hydrophobicity 0.913
Hydrophilicity 0.719
Buriedness 0.724
Don/acc character 1.325
SiteScore 1.210
D Score 1.116