HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Complex 8fc4

System information

Experimental technique X-ray
Experimental resolution 2.45
System mass 4426.45 kDa
Deposition year 2022
Molecule type RNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 8fc4
Reference Chen Chih-Wei, Leimer Nadja, Syroegin Egor A., Dunand Clémence, Bulman Zackery P., Lewis Kim, Polikanov Yury S., Svetlov Maxim S.. . Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A Nature Communications

Compound ARG
Residue . / 230
Chain TRA / 1B
Non-redundant True
Interacting RNA chains B/1B
Volume 123.14 Å3
Hydrophobicity 0.034
Hydrophilicity 2.003
Buriedness 0.605
Don/acc character 0.929
SiteScore 0.913
D Score 0.426

Compound ARG
Residue . / 318
Chain KTA / 1F
Non-redundant True
Interacting RNA chains A/1A
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -

Compound ERY
Residue . / 4027
Chain OQA / 1A
Non-redundant True
Interacting RNA chains A/1A
Volume 403.37 Å3
Hydrophobicity 0.253
Hydrophilicity 1.322
Buriedness 0.736
Don/acc character 0.667
SiteScore 1.025
D Score 0.951

Compound HGR
Residue . / 4026
Chain NQA / 1A
Non-redundant True
Interacting RNA chains A/1A
Volume 772.09 Å3
Hydrophobicity 0.495
Hydrophilicity 1.455
Buriedness 0.735
Don/acc character 0.565
SiteScore 1.175
D Score 0.907

Compound HGR
Residue . / 3671
Chain QIC / 2A
Non-redundant True
Interacting RNA chains BB/2A
Volume 490.83 Å3
Hydrophobicity 0.900
Hydrophilicity 0.900
Buriedness 0.787
Don/acc character 1.222
SiteScore 1.236
D Score 1.119