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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 8evr

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.87
System mass 3318.51 kDa
Deposition year 2022
Molecule type RNA/Protein
# RNA entities 1
Organism Saccharomyces
RCSB PDB Entry 8evr
Reference Zhao Yu, Rai Jay, Li Hong. 2023. Regulation of translation by ribosomal RNA pseudouridylation Science Advances
Equivalence Class NR_all_90506.85
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GDP
Residue . / 901
Chain NK / DC
Non-redundant True
Interacting RNA chains LA/A1
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains LA/A1: rRNA
RNA family global rRNA
Volume 651.01 Å3
Hydrophobicity 0.036
Hydrophilicity 1.691
Buriedness 0.750
Don/acc character 0.627
SiteScore 1.035
D Score 0.839
Kd