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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 8e3o

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 1.99
System mass 1110.45 kDa
Deposition year 2022
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 8e3o
Equivalence Class NR_all_83717.187
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound EM1
Residue . / 3001
Chain K / I
Non-redundant True
Interacting RNA chains A/I
RNA environment detailled protein, other
RNA environment global RNA/Other
RNA family chains A/I: rRNA
RNA family global rRNA
Volume 428.41 Å3
Hydrophobicity 0.120
Hydrophilicity 1.350
Buriedness 0.817
Don/acc character 1.374
SiteScore 1.006
D Score 0.896
Kd

Compound VIR
Residue . / 3002
Chain L / I
Non-redundant True
Interacting RNA chains A/I
RNA environment detailled other
RNA environment global RNA/Other
RNA family chains A/I: rRNA
RNA family global rRNA
Volume 494.26 Å3
Hydrophobicity 1.082
Hydrophilicity 0.713
Buriedness 0.800
Don/acc character 2.157
SiteScore 1.138
D Score 1.011
Kd