Complex 8c8j

Legend

Pocket colors by molecule type

RNA

Protein

DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique	X-ray
Experimental resolution	2.10
System mass	106.64 kDa
Deposition year	2023
Molecule type	RNA/DNA/Protein
# RNA entities	1
Organism	N/A
RCSB PDB Entry	8c8j
Reference	Baldwin Eric T., van Eeuwen Trevor, Hoyos David, Zalevsky Arthur, Tchesnokov Egor P., Sánchez Roberto, Miller Bryant D., Di Stefano Luciano H., Ruiz Francesc Xavier, Hancock Matthew, Işik Esin, Mendez-Dorantes Carlos, Walpole Thomas, Nichols Charles, Wan Paul, Riento Kirsi, Halls-Kass Rowan, Augustin Martin, Lammens Alfred, Jestel Anja, Upla Paula, Xibinaku Kera, Congreve Samantha, Hennink Maximiliaan, Rogala Kacper B., Schneider Anna M., Fairman Jennifer E., Christensen Shawn M., Desrosiers Brian, Bisacchi Gregory S., Saunders Oliver L., Hafeez Nafeeza, Miao Wenyan, Kapeller Rosana, Zaller Dennis M., Sali Andrej, Weichenrieder Oliver, Burns Kathleen H., Götte Matthias, Rout Michael P., Arnold Eddy, Greenbaum Benjamin D., Romero Donna L., LaCava John, Taylor Martin S.. 2024. Structures, functions and adaptations of the human LINE-1 ORF2 protein Nature
Equivalence Class	NR_all_67275.1 BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

Favourable

Intermediate

Unfavourable

Not available

Score	Threshold	Meaning
SiteScore	< 0.8	Non-drug binding site
SiteScore	0.8 – 1.0	Potential drug binding site
SiteScore	> 1.0	Promising binding site
D Score	< 0.83	Undruggable
D Score	0.83 – 0.98	Difficult
D Score	> 0.98	Druggable

Tick a pocket below to highlight it in the 3D structure above.

Pocket 1

Compound	TTP
Residue	. / 1102
Chain	E / A
Non-redundant	True
Interacting RNA chains	C/C
RNA environment detailled	DNA, protein, ion
RNA environment global	RNA/DNA/Protein
RNA family chains	C/C: synthetic construct
RNA family global	synthetic construct
Volume	233.93 Å³
Hydrophobicity	0.421
Hydrophilicity	1.584
Buriedness	0.770
Don/acc character	0.281
SiteScore	1.048
D Score	0.885
Kd	—