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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 8bn3

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.40
System mass 2979.33 kDa
Deposition year 2022
Molecule type RNA/Protein
# RNA entities 1
Organism Saccharomyces
RCSB PDB Entry 8bn3
Reference Rauscher Robert, Eggers Cristian, Dimitrova-Paternoga Lyudmila, Shankar Vaishnavi, Rosina Alessia, Cristodero Marina, Paternoga Helge, Wilson Daniel N, Leidel Sebastian A, Polacek Norbert. 2024. Evolving precision: rRNA expansion segment 7S modulates translation velocity and accuracy in eukaryal ribosomes Nucleic Acids Research
Equivalence Class NR_all_90506.85
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 3HE
Residue . / 3464
Chain TE / 1
Non-redundant True
Interacting RNA chains M/1
RNA environment detailled protein, other
RNA environment global RNA/Other
RNA family chains M/1: rRNA
RNA family global rRNA
Volume 451.05 Å3
Hydrophobicity 0.321
Hydrophilicity 1.156
Buriedness 0.809
Don/acc character 1.043
SiteScore 1.075
D Score 1.049
Kd