Complex 7uo7
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 3.09 |
| System mass | 190.30 kDa |
| Deposition year | 2022 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | N/A |
| RCSB PDB Entry | 7uo7 |
| Reference | Malone Brandon F., Perry Jason K., Olinares Paul Dominic B., Lee Hery W., Chen James, Appleby Todd C., Feng Joy Y., Bilello John P., Ng Honkit, Sotiris Johanna, Ebrahim Mark, Chua Eugene Y. D., Mendez Joshua H., Eng Ed T., Landick Robert, Götte Matthias, Chait Brian T., Campbell Elizabeth A., Darst Seth A.. 2023. Structural basis for substrate selection by the SARS-CoV-2 replicase Nature |
| Equivalence Class |
NR_all_58300.4
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | ATP |
| Residue | . / 1001 |
| Chain | G / A |
| Non-redundant | True |
| Interacting RNA chains | E/T, D/P |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | D/P: synthetic construct, E/T: synthetic construct |
| RNA family global | synthetic construct |
| Volume | 748.08 Å3 |
| Hydrophobicity | 0.299 |
| Hydrophilicity | 1.421 |
| Buriedness | 0.824 |
| Don/acc character | 0.606 |
| SiteScore | 1.084 |
| D Score | 0.971 |
| Kd | — |