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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7s1h

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.35
System mass 2144.98 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 7s1h
Reference Tsai Kaitlyn, Stojković Vanja, Lee D. John, Young Iris D., Szal Teresa, Klepacki Dorota, Vázquez-Laslop Nora, Mankin Alexander S., Fraser James S., Fujimori Danica Galonić. 2022. Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics Nature Structural & Molecular Biology
Equivalence Class NR_all_83717.187, NR_all_10157.185
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ZLD
Residue . / 3114
Chain UI / I
Non-redundant True
Interacting RNA chains J/I
RNA environment detailled ion
RNA environment global RNA
RNA family chains J/I: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd