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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7qiz

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.38
System mass 3177.26 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Solanum
RCSB PDB Entry 7qiz
Reference Cottilli Patrick, Itoh Yuzuru, Nobe Yuko, Petrov Anton S., Lisón Purificación, Taoka Masato, Amunts Alexey. 2022. Cryo-EM structure and rRNA modification sites of a plant ribosome Plant Communications
Equivalence Class NR_all_95195.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 3479
Chain VF / 2
Non-redundant True
Interacting RNA chains QA/2
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains QA/2: rRNA
RNA family global rRNA
Volume 715.50 Å3
Hydrophobicity 0.303
Hydrophilicity 1.408
Buriedness 0.858
Don/acc character 1.090
SiteScore 1.107
D Score 0.996
Kd

Compound SPM
Residue . / 3480
Chain WF / 2
Non-redundant True
Interacting RNA chains QA/2
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains QA/2: rRNA
RNA family global rRNA
Volume 901.75 Å3
Hydrophobicity 0.146
Hydrophilicity 1.672
Buriedness 0.894
Don/acc character 0.997
SiteScore 1.131
D Score 0.931
Kd

Compound SPM
Residue . / 3482
Chain YF / 2
Non-redundant True
Interacting RNA chains SA/8, QA/2
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains QA/2: rRNA, SA/8: rRNA
RNA family global rRNA
Volume 1047.52 Å3
Hydrophobicity 0.437
Hydrophilicity 1.339
Buriedness 0.869
Don/acc character 0.953
SiteScore 1.115
D Score 1.025
Kd