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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7qiw

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.35
System mass 1992.65 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Solanum
RCSB PDB Entry 7qiw
Reference Cottilli Patrick, Itoh Yuzuru, Nobe Yuko, Petrov Anton S., Lisón Purificación, Taoka Masato, Amunts Alexey. 2022. Cryo-EM structure and rRNA modification sites of a plant ribosome Plant Communications
Equivalence Class NR_all_95195.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 3480
Chain OE / 2
Non-redundant True
Interacting RNA chains QA/2
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains QA/2: rRNA
RNA family global rRNA
Volume 713.44 Å3
Hydrophobicity 0.250
Hydrophilicity 1.425
Buriedness 0.860
Don/acc character 1.094
SiteScore 1.108
D Score 0.992
Kd

Compound SPM
Residue . / 3481
Chain PE / 2
Non-redundant True
Interacting RNA chains QA/2
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains QA/2: rRNA
RNA family global rRNA
Volume 906.21 Å3
Hydrophobicity 0.166
Hydrophilicity 1.651
Buriedness 0.893
Don/acc character 0.971
SiteScore 1.131
D Score 0.938
Kd

Compound SPM
Residue . / 3483
Chain RE / 2
Non-redundant True
Interacting RNA chains SA/8, QA/2
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains QA/2: rRNA, SA/8: rRNA
RNA family global rRNA
Volume 960.74 Å3
Hydrophobicity 0.381
Hydrophilicity 1.406
Buriedness 0.883
Don/acc character 0.791
SiteScore 1.123
D Score 1.011
Kd