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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7q4k

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.00
System mass 2196.09 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 7q4k
Reference Fostier Corentin R., Ousalem Farès, Leroy Elodie C., Ngo Saravuth, Soufari Heddy, Innis C. Axel, Hashem Yaser, Boël Grégory. 2023. Regulation of the macrolide resistance ABC-F translation factor MsrD Nature Communications
Equivalence Class NR_all_83717.187
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ERY
Residue . / 3001
Chain NC / BA
Non-redundant True
Interacting RNA chains V/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains V/BA: rRNA
RNA family global rRNA
Volume 731.96 Å3
Hydrophobicity 0.431
Hydrophilicity 1.249
Buriedness 0.807
Don/acc character 1.290
SiteScore 1.073
D Score 1.017
Kd