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HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7pub

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.70
System mass 3617.43 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Trypanosoma
RCSB PDB Entry 7pub
Reference Lenarčič Tea, Niemann Moritz, Ramrath David J. F., Calderaro Salvatore, Flügel Timo, Saurer Martin, Leibundgut Marc, Boehringer Daniel, Prange Céline, Horn Elke K., Schneider André, Ban Nenad. 2022. Mitoribosomal small subunit maturation involves formation of initiation-like complexes Proceedings of the National Academy of Sciences
Equivalence Class NR_all_60828.8
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound UTP
Residue . / 401
Chain GC / DJ
Non-redundant True
Interacting RNA chains A/CA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains A/CA: rRNA
RNA family global rRNA
Volume 254.85 Å3
Hydrophobicity 0.215
Hydrophilicity 1.459
Buriedness 0.742
Don/acc character 0.602
SiteScore 0.923
D Score 0.773
Kd