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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7pny

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.06
System mass 1217.89 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 7pny
Reference Itoh Yuzuru, Khawaja Anas, Laptev Ivan, Cipullo Miriam, Atanassov Ilian, Sergiev Petr, Rorbach Joanna, Amunts Alexey. 2022. Mechanism of mitoribosomal small subunit biogenesis and preinitiation Nature
Equivalence Class NR_all_93855.32
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound NAD
Residue . / 1701
Chain GA / A
Non-redundant False
Interacting RNA chains A/A
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 1206.67 Å3
Hydrophobicity 0.442
Hydrophilicity 1.209
Buriedness 0.850
Don/acc character 1.154
SiteScore 1.251
D Score 1.055
Kd