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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7phb

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 4.90
System mass 2283.91 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Mycoplasmoides
RCSB PDB Entry 7phb
Reference Xue Liang, Lenz Swantje, Zimmermann-Kogadeeva Maria, Tegunov Dimitry, Cramer Patrick, Bork Peer, Rappsilber Juri, Mahamid Julia. 2022. Visualizing translation dynamics at atomic detail inside a bacterial cell Nature
Equivalence Class NR_all_06181.4
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound CLM
Residue . / 3001
Chain EB / 3
Non-redundant True
Interacting RNA chains YA/3
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains YA/3: rRNA
RNA family global rRNA
Volume 743.97 Å3
Hydrophobicity 0.623
Hydrophilicity 1.199
Buriedness 0.854
Don/acc character 1.546
SiteScore 1.254
D Score 1.061
Kd