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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7p3k

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.90
System mass 2117.18 kDa
Deposition year 2021
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 7p3k
Reference Su Ting, Kudva Renuka, Becker Thomas, Buschauer Robert, Komar Tobias, Berninghausen Otto, von Heijne Gunnar, Cheng Jingdong, Beckmann Roland. 2021. Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide Nucleic Acids Research
Equivalence Class NR_all_83717.187, NR_all_56633.10
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound CLM
Residue . / 6206
Chain OM / a
Non-redundant True
Interacting RNA chains V/a
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains V/a: rRNA
RNA family global rRNA
Volume 740.19 Å3
Hydrophobicity 0.468
Hydrophilicity 1.038
Buriedness 0.767
Don/acc character 1.902
SiteScore 1.196
D Score 1.061
Kd