Complex 7nwg
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 3.80 |
| System mass | 3512.38 kDa |
| Deposition year | 2021 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Oryctolagus |
| RCSB PDB Entry | 7nwg |
| Reference | Powers Kyle T, Stevenson-Jones Flint, Yadav Sathish K N, Amthor Beate, Bufton Joshua C, Borucu Ufuk, Shen Dakang, Becker Jonas P, Lavysh Daria, Hentze Matthias W, Kulozik Andreas E, Neu-Yilik Gabriele, Schaffitzel Christiane. 2021. Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA Nucleic Acids Research |
| Equivalence Class |
NR_all_06650.50,
NR_all_20988.1
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | BLS |
| Residue | . / 5294 |
| Chain | TJ / 51 |
| Non-redundant | True |
| Interacting RNA chains | A/51, AC/q3 |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | A/51: rRNA, AC/q3: tRNA |
| RNA family global | multiple |
| Volume | 773.47 Å3 |
| Hydrophobicity | 0.391 |
| Hydrophilicity | 0.954 |
| Buriedness | 0.728 |
| Don/acc character | 2.506 |
| SiteScore | 1.187 |
| D Score | 1.066 |
| Kd | — |