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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 7kqn

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.02
System mass 164.17 kDa
Deposition year 2020
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism Tribolium
RCSB PDB Entry 7kqn
Reference Choi Woo Suk, Weng Peter J., Yang Wei. 2022. Flexibility of telomerase in binding the RNA template and DNA telomeric repeat Proceedings of the National Academy of Sciences
Equivalence Class NR_all_27305.2
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound DGT
Residue . / 615
Chain W / A
Non-redundant True
Interacting RNA chains B/B
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains B/B: telomerase_RNA
RNA family global telomerase_RNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound DGT
Residue . / 613
Chain JA / D
Non-redundant True
Interacting RNA chains E/E
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains E/E: telomerase_RNA
RNA family global telomerase_RNA
Volume 700.06 Å3
Hydrophobicity 0.166
Hydrophilicity 1.559
Buriedness 0.767
Don/acc character 0.489
SiteScore 1.046
D Score 0.892
Kd