Complex 6y69

Legend

Pocket colors by molecule type

RNA

Protein

DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique	Electron Microscopy
Experimental resolution	2.86
System mass	2141.15 kDa
Deposition year	2020
Molecule type	RNA/Protein
# RNA entities	1
Organism	Escherichia
RCSB PDB Entry	6y69
Reference	Osterman Ilya A., Wieland Maximiliane, Maviza Tinashe P., Lashkevich Kseniya A., Lukianov Dmitrii A., Komarova Ekaterina S., Zakalyukina Yuliya V., Buschauer Robert, Shiriaev Dmitrii I., Leyn Semen A., Zlamal Jaime E., Biryukov Mikhail V., Skvortsov Dmitry A., Tashlitsky Vadim N., Polshakov Vladimir I., Cheng Jingdong, Polikanov Yury S., Bogdanov Alexey A., Osterman Andrei L., Dmitriev Sergey E., Beckmann Roland, Dontsova Olga A., Wilson Daniel N., Sergiev Petr V.. 2020. Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel Nature Chemical Biology
Equivalence Class	NR_all_83717.187 BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

Favourable

Intermediate

Unfavourable

Not available

Score	Threshold	Meaning
SiteScore	< 0.8	Non-drug binding site
SiteScore	0.8 – 1.0	Potential drug binding site
SiteScore	> 1.0	Promising binding site
D Score	< 0.83	Undruggable
D Score	0.83 – 0.98	Difficult
D Score	> 0.98	Druggable

Tick a pocket below to highlight it in the 3D structure above.

Pocket 1

Compound	OCW
Residue	. / 3001
Chain	CB / A
Non-redundant	True
Interacting RNA chains	V/A
RNA environment detailled	ion
RNA environment global	RNA
RNA family chains	V/A: rRNA
RNA family global	rRNA
Volume	436.64 Å³
Hydrophobicity	0.289
Hydrophilicity	0.944
Buriedness	0.707
Don/acc character	2.959
SiteScore	1.141
D Score	1.013
Kd	—