HARIBOSS logo

HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6y0g

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.20
System mass 3839.71 kDa
Deposition year 2020
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 6y0g
Reference Bhaskar Varun, Graff-Meyer Alexandra, Schenk Andreas D., Cavadini Simone, von Loeffelholz Ottilie, Natchiar S. Kundhavai, Artus-Revel Caroline G., Hotz Hans-Rudolf, Bretones Gabriel, Klaholz Bruno P., Chao Jeffrey A.. 2020. Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes Cell Reports
Equivalence Class NR_all_65061.63
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 3HE
Residue . / 5101
Chain GC / L5
Non-redundant True
Interacting RNA chains E/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains E/L5: rRNA
RNA family global rRNA
Volume 252.79 Å3
Hydrophobicity 0.268
Hydrophilicity 0.860
Buriedness 0.611
Don/acc character 1.130
SiteScore 0.943
D Score 0.790
Kd