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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6wrs

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.20
System mass 1295.92 kDa
Deposition year 2020
Molecule type RNA/Protein
# RNA entities 1
Organism Staphylococcus
RCSB PDB Entry 6wrs
Reference Wright Alexander, Deane-Alder Kieran, Marschall Edward, Bamert Rebecca, Venugopal Hari, Lithgow Trevor, Lupton David W., Belousoff Matthew J.. 2020. Characterization of the Core Ribosomal Binding Region for the Oxazolidone Family of Antibiotics Using Cryo-EM ACS Pharmacology & Translational Science
Equivalence Class NR_all_90633.30
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound U7V
Residue . / 3001
Chain BA / 1
Non-redundant True
Interacting RNA chains Y/1
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains Y/1: rRNA
RNA family global rRNA
Volume 366.67 Å3
Hydrophobicity 0.268
Hydrophilicity 1.105
Buriedness 0.737
Don/acc character 3.224
SiteScore 1.176
D Score 1.022
Kd