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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6woy

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.00
System mass 441.21 kDa
Deposition year 2020
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 6woy
Reference Mäkinen Janne J., Shin Yeonoh, Vieras Eeva, Virta Pasi, Metsä-Ketelä Mikko, Murakami Katsuhiko S., Belogurov Georgiy A.. 2021. The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases Nature Communications

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound CH1
Residue . / 101
Chain N / I
Non-redundant True
Interacting RNA chains I/I
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains I/I: unknown
RNA family global unknown
Volume 276.46 Å3
Hydrophobicity 0.341
Hydrophilicity 1.324
Buriedness 0.763
Don/acc character 1.219
SiteScore 0.613
D Score 0.414
Kd