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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6tz2

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.50
System mass 231.98 kDa
Deposition year 2019
Molecule type RNA/Protein
# RNA entities 1
Organism Cypovirus
RCSB PDB Entry 6tz2
Reference Cui Yanxiang, Zhang Yinong, Zhou Kang, Sun Jingchen, Zhou Z. Hong. 2019. Conservative transcription in three steps visualized in a double-stranded RNA virus Nature Structural & Molecular Biology
Equivalence Class NR_all_22144.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ATP
Residue . / 1301
Chain F / A
Non-redundant True
Interacting RNA chains D/N
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains D/N: unknown
RNA family global unknown
Volume 515.19 Å3
Hydrophobicity 0.373
Hydrophilicity 1.191
Buriedness 0.763
Don/acc character 0.747
SiteScore 1.043
D Score 1.009
Kd

Compound UTP
Residue . / 1302
Chain G / A
Non-redundant True
Interacting RNA chains C/M, E/T
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains C/M: unknown, E/T: unknown
RNA family global unknown
Volume 699.03 Å3
Hydrophobicity 0.349
Hydrophilicity 1.489
Buriedness 0.842
Don/acc character 0.686
SiteScore 1.096
D Score 0.960
Kd