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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6p1s

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 1.75
System mass 46.31 kDa
Deposition year 2019
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 6p1s
Reference Kaminski Andrea M, Chiruvella Kishore K, Ramsden Dale A, Kunkel Thomas A, Bebenek Katarzyna, Pedersen Lars C. 2019. Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2′-guanosine Nucleic Acids Research

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ATP
Residue . / 501
Chain E / A
Non-redundant True
Interacting RNA chains C/P
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains C/P: RNA/DNA_hybrid
RNA family global RNA/DNA_hybrid
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd