Complex 6om7
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 3.70 |
| System mass | 3182.62 kDa |
| Deposition year | 2019 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Homo |
| RCSB PDB Entry | 6om7 |
| Reference | Li Wenfei, Ward Fred R., McClure Kim F., Chang Stacey Tsai-Lan, Montabana Elizabeth, Liras Spiros, Dullea Robert G., Cate Jamie H. D.. 2019. Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule Nature Structural & Molecular Biology |
| Equivalence Class |
NR_all_65061.63
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | MVM |
| Residue | . / 5112 |
| Chain | QD / t |
| Non-redundant | True |
| Interacting RNA chains | AC/t |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | AC/t: rRNA |
| RNA family global | rRNA |
| Volume | 269.26 Å3 |
| Hydrophobicity | 0.198 |
| Hydrophilicity | 1.348 |
| Buriedness | 0.791 |
| Don/acc character | 0.710 |
| SiteScore | 0.541 |
| D Score | 0.505 |
| Kd | — |