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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6ogz

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.60
System mass 1171.58 kDa
Deposition year 2019
Molecule type RNA/Protein
# RNA entities 1
Organism Rotavirus
RCSB PDB Entry 6ogz
Reference Ding Ke, Celma Cristina C., Zhang Xing, Chang Thomas, Shen Wesley, Atanasov Ivo, Roy Polly, Zhou Z. Hong. 2019. In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release Nature Communications
Equivalence Class NR_all_30784.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound UTP
Residue . / 1101
Chain N / A
Non-redundant True
Interacting RNA chains B/C, A/B
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains A/B: unknown, B/C: unknown
RNA family global unknown
Volume 591.33 Å3
Hydrophobicity 0.170
Hydrophilicity 1.673
Buriedness 0.869
Don/acc character 0.731
SiteScore 1.114
D Score 0.916
Kd