HARIBOSS logo

HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6n9x

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 4.10
System mass 473.98 kDa
Deposition year 2018
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism Teseptimavirus
RCSB PDB Entry 6n9x
Reference Gao Yang, Cui Yanxiang, Fox Tara, Lin Shiqiang, Wang Huaibin, de Val Natalia, Zhou Z. Hong, Yang Wei. 2019. Structures and operating principles of the replisome Science

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound TTP
Residue . / 801
Chain S / H
Non-redundant True
Interacting RNA chains H/P
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains H/P: RNA/DNA_hybrid
RNA family global RNA/DNA_hybrid
Volume 739.17 Å3
Hydrophobicity 0.738
Hydrophilicity 1.073
Buriedness 0.825
Don/acc character 0.613
SiteScore 1.085
D Score 1.085
Kd