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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6k32

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.20
System mass 883.38 kDa
Deposition year 2019
Molecule type RNA/Protein
# RNA entities 1
Organism Cypovirus
RCSB PDB Entry 6k32
Reference Li Xiaowu, Wang Li, Wang Xurong, Chen Wenyuan, Yang Tao, Song Jingdong, Liu Hongrong, Cheng Lingpeng. 2020. Structure of RdRps Within a Transcribing dsRNA Virus Provides Insights Into the Mechanisms of RNA Synthesis Journal of Molecular Biology
Equivalence Class NR_all_45323.2, NR_all_81264.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound UTP
Residue . / 1306
Chain O / A
Non-redundant True
Interacting RNA chains C/t, D/p
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains C/t: unknown, D/p: unknown
RNA family global unknown
Volume 486.37 Å3
Hydrophobicity 0.150
Hydrophilicity 1.646
Buriedness 0.875
Don/acc character 0.400
SiteScore 1.119
D Score 0.929
Kd