Complex 6izp

Legend

Pocket colors by molecule type

RNA

Protein

DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique	Solution NMR
Experimental resolution	N/A
System mass	10.33 kDa
Deposition year	2018
Molecule type	RNA
# RNA entities	1
Organism	Homo
RCSB PDB Entry	6izp
Reference	Shibata Tomonori, Nagano Konami, Ueyama Morio, Ninomiya Kensuke, Hirose Tetsuro, Nagai Yoshitaka, Ishikawa Kinya, Kawai Gota, Nakatani Kazuhiko. 2021. Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model Nature Communications
Equivalence Class	NR_all_51853.1 BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

Favourable

Intermediate

Unfavourable

Not available

Score	Threshold	Meaning
SiteScore	< 0.8	Non-drug binding site
SiteScore	0.8 – 1.0	Potential drug binding site
SiteScore	> 1.0	Promising binding site
D Score	< 0.83	Undruggable
D Score	0.83 – 0.98	Difficult
D Score	> 0.98	Druggable

Tick a pocket below to highlight it in the 3D structure above.

Pocket 1

Compound	B2R
Residue	. / 101
Chain	B / A
Non-redundant	True
Interacting RNA chains	A/A
RNA environment detailled	other
RNA environment global	RNA/Other
RNA family chains	A/A: unknown
RNA family global	unknown
Volume	47.33 Å³
Hydrophobicity	0.294
Hydrophilicity	1.027
Buriedness	0.602
Don/acc character	0.776
SiteScore	0.640
D Score	0.391
Kd	—

Pocket 2

Compound	B2R
Residue	. / 102
Chain	C / A
Non-redundant	False
Interacting RNA chains	A/A
RNA environment detailled	other
RNA environment global	RNA/Other
RNA family chains	A/A: unknown
RNA family global	unknown
Volume	56.94 Å³
Hydrophobicity	0.094
Hydrophilicity	1.088
Buriedness	0.550
Don/acc character	1.960
SiteScore	0.670
D Score	0.426
Kd	—