Complex 6hmo
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Solution NMR |
| Experimental resolution | N/A |
| System mass | 7.37 kDa |
| Deposition year | 2018 |
| Molecule type | RNA |
| # RNA entities | 1 |
| Organism | Homo |
| RCSB PDB Entry | 6hmo |
| Reference | Campagne Sébastien, Boigner Sarah, Rüdisser Simon, Moursy Ahmed, Gillioz Laurent, Knörlein Anna, Hall Jonathan, Ratni Hasane, Cléry Antoine, Allain Frédéric H.-T.. 2019. Structural basis of a small molecule targeting RNA for a specific splicing correction Nature Chemical Biology |
| Molecular Dynamics Simulation | mmb-A01WS, mmb-A01XJ, mmb-A01YI, mmb-A022C, mmb-A022L |
| Equivalence Class |
NR_all_79155.3
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | GDZ |
| Residue | . / 101 |
| Chain | C / A |
| Non-redundant | True |
| Interacting RNA chains | A/A, B/B |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/A: sre_rna, B/B: sre_rna |
| RNA family global | sre_rna |
| Volume | 29.16 Å3 |
| Hydrophobicity | 0.006 |
| Hydrophilicity | 0.583 |
| Buriedness | 0.404 |
| Don/acc character | 3.369 |
| SiteScore | 0.956 |
| D Score | 0.883 |
| Kd | 28uM |