Complex 6hko
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 3.42 |
| System mass | 621.02 kDa |
| Deposition year | 2018 |
| Molecule type | RNA/DNA/Protein |
| # RNA entities | 1 |
| Organism | Saccharomyces |
| RCSB PDB Entry | 6hko |
| Reference | Tafur Lucas, Sadian Yashar, Hanske Jonas, Wetzel Rene, Weis Felix, Müller Christoph W. 2019. The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2 eLife |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | G2P |
| Residue | . / 3000 |
| Chain | Y / T |
| Non-redundant | True |
| Interacting RNA chains | M/R |
| RNA environment detailled | DNA, protein, ion |
| RNA environment global | RNA/DNA/Protein |
| RNA family chains | M/R: unknown |
| RNA family global | unknown |
| Volume | 741.57 Å3 |
| Hydrophobicity | 0.521 |
| Hydrophilicity | 1.309 |
| Buriedness | 0.812 |
| Don/acc character | 0.926 |
| SiteScore | 1.076 |
| D Score | 1.000 |
| Kd | — |