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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6hiz

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.08
System mass 1650.37 kDa
Deposition year 2018
Molecule type RNA/Protein
# RNA entities 1
Organism Trypanosoma
RCSB PDB Entry 6hiz
Reference Ramrath David J. F., Niemann Moritz, Leibundgut Marc, Bieri Philipp, Prange Céline, Horn Elke K., Leitner Alexander, Boehringer Daniel, Schneider André, Ban Nenad. 2018. Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes Science
Equivalence Class NR_all_60828.8
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound UTP
Residue . / 401
Chain DA / DJ
Non-redundant True
Interacting RNA chains Z/CA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains Z/CA: rRNA
RNA family global rRNA
Volume 204.09 Å3
Hydrophobicity 0.256
Hydrophilicity 1.253
Buriedness 0.723
Don/acc character 0.508
SiteScore 0.856
D Score 0.759
Kd