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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6hiv

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 7.80
System mass 5396.18 kDa
Deposition year 2018
Molecule type RNA/Protein
# RNA entities 1
Organism Trypanosoma
RCSB PDB Entry 6hiv
Reference Ramrath David J. F., Niemann Moritz, Leibundgut Marc, Bieri Philipp, Prange Céline, Horn Elke K., Leitner Alexander, Boehringer Daniel, Schneider André, Ban Nenad. 2018. Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes Science
Equivalence Class NR_all_60828.8
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 738
Chain VG / CA
Non-redundant True
Interacting RNA chains EB/CA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains EB/CA: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound UTP
Residue . / 401
Chain CF / DJ
Non-redundant True
Interacting RNA chains EB/CA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains EB/CA: rRNA
RNA family global rRNA
Volume 272.69 Å3
Hydrophobicity 0.410
Hydrophilicity 1.204
Buriedness 0.707
Don/acc character 0.519
SiteScore 0.937
D Score 0.883
Kd