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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6hd7

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.40
System mass 2146.18 kDa
Deposition year 2018
Molecule type RNA/Protein
# RNA entities 1
Organism Saccharomyces
RCSB PDB Entry 6hd7
Reference Knorr Alexandra G., Schmidt Christian, Tesina Petr, Berninghausen Otto, Becker Thomas, Beatrix Birgitta, Beckmann Roland. 2019. Ribosome–NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation Nature Structural & Molecular Biology
Equivalence Class NR_all_90506.85, NR_all_45609.8
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 3HE
Residue . / 3401
Chain ZA / 1
Non-redundant True
Interacting RNA chains A/1
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains A/1: rRNA
RNA family global rRNA
Volume 590.99 Å3
Hydrophobicity 0.327
Hydrophilicity 1.202
Buriedness 0.805
Don/acc character 1.233
SiteScore 1.072
D Score 1.031
Kd