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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6gxo

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.90
System mass 2249.80 kDa
Deposition year 2018
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 6gxo
Reference Graf Michael, Huter Paul, Maracci Cristina, Peterek Miroslav, Rodnina Marina V., Wilson Daniel N.. 2018. Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1 Nature Communications
Equivalence Class NR_all_83717.187
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GCP
Residue . / 601
Chain GB / w
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 474.37 Å3
Hydrophobicity 0.506
Hydrophilicity 1.158
Buriedness 0.737
Don/acc character 0.669
SiteScore 1.026
D Score 1.005
Kd