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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6gaz

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Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.10
System mass 1334.80 kDa
Deposition year 2018
Molecule type RNA/Protein
# RNA entities 1
Organism Sus
RCSB PDB Entry 6gaz
Reference Kummer Eva, Leibundgut Marc, Rackham Oliver, Lee Richard G., Boehringer Daniel, Filipovska Aleksandra, Ban Nenad. 2018. Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM Nature
Equivalence Class NR_all_19551.9
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 3001
Chain OA / AA
Non-redundant True
Interacting RNA chains C/AA
RNA environment detailled ion
RNA environment global RNA
RNA family chains C/AA: rRNA
RNA family global rRNA
Volume 511.07 Å3
Hydrophobicity 0.274
Hydrophilicity 1.057
Buriedness 0.794
Don/acc character 2.734
SiteScore 1.214
D Score 1.072
Kd