Complex 6ck5
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.49 |
| System mass | 79.23 kDa |
| Deposition year | 2018 |
| Molecule type | RNA |
| # RNA entities | 1 |
| Organism | Thermoanaerobacter |
| RCSB PDB Entry | 6ck5 |
| Reference | Knappenberger Andrew John, Reiss Caroline Wetherington, Strobel Scott A. 2018. Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA eLife |
| Equivalence Class |
NR_all_40570.3
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | PRP |
| Residue | . / 217 |
| Chain | S / A |
| Non-redundant | True |
| Interacting RNA chains | A/A |
| RNA environment detailled | ion |
| RNA environment global | RNA |
| RNA family chains | A/A: riboswitch |
| RNA family global | riboswitch |
| Volume | 577.61 Å3 |
| Hydrophobicity | 0.129 |
| Hydrophilicity | 1.746 |
| Buriedness | 0.780 |
| Don/acc character | 0.771 |
| SiteScore | 1.201 |
| D Score | 0.834 |
| Kd | 2.0uM |
| Compound | PRP |
| Residue | . / 216 |
| Chain | IA / B |
| Non-redundant | False |
| Interacting RNA chains | B/B |
| RNA environment detailled | ion |
| RNA environment global | RNA |
| RNA family chains | B/B: riboswitch |
| RNA family global | riboswitch |
| Volume | 632.49 Å3 |
| Hydrophobicity | 0.036 |
| Hydrophilicity | 1.750 |
| Buriedness | 0.776 |
| Don/acc character | 0.954 |
| SiteScore | 1.202 |
| D Score | 0.835 |
| Kd | 2.0uM |