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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6chr

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.70
System mass 208.64 kDa
Deposition year 2018
Molecule type RNA
# RNA entities 1
Organism Pylaiella
RCSB PDB Entry 6chr
Reference Chan Russell T., Peters Jessica K., Robart Aaron R., Wiryaman Timothy, Rajashankar Kanagalaghatta R., Toor Navtej. 2018. Structural basis for the second step of group II intron splicing Nature Communications
Equivalence Class NR_all_18903.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 741
Chain QA / A
Non-redundant False
Interacting RNA chains A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: ribozyme
RNA family global ribozyme
Volume 359.12 Å3
Hydrophobicity 0.071
Hydrophilicity 1.040
Buriedness 0.631
Don/acc character 1.504
SiteScore 1.011
D Score 0.859
Kd