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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6bsh

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.65
System mass 131.60 kDa
Deposition year 2017
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 6bsh
Reference Tian Lan, Kim Min-Sung, Li Hongzhi, Wang Jimin, Yang Wei. 2018. Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid Proceedings of the National Academy of Sciences
Equivalence Class NR_all_20621.2
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound TAM
Residue . / 101
Chain N / R
Non-redundant True
Interacting RNA chains D/R
RNA environment detailled DNA
RNA environment global RNA/DNA
RNA family chains D/R: TAR_rna
RNA family global TAR_rna
Volume 163.61 Å3
Hydrophobicity 0.000
Hydrophilicity 1.251
Buriedness 0.663
Don/acc character 1.549
SiteScore 0.767
D Score 0.469
Kd