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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6ar1

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.01
System mass 116.36 kDa
Deposition year 2017
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism N/A
RCSB PDB Entry 6ar1
Reference Stamos Jennifer L., Lentzsch Alfred M., Lambowitz Alan M.. 2017. Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications Molecular Cell
Equivalence Class NR_all_10432.2
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound DTP
Residue . / 501
Chain G / A
Non-redundant True
Interacting RNA chains C/C
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains C/C: ribozyme
RNA family global ribozyme
Volume 606.08 Å3
Hydrophobicity 0.277
Hydrophilicity 1.649
Buriedness 0.843
Don/acc character 0.583
SiteScore 1.097
D Score 0.908
Kd

Compound DTP
Residue . / 501
Chain J / D
Non-redundant True
Interacting RNA chains F/F
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains F/F: ribozyme
RNA family global ribozyme
Volume 513.47 Å3
Hydrophobicity 0.298
Hydrophilicity 1.562
Buriedness 0.826
Don/acc character 0.624
SiteScore 1.085
D Score 0.926
Kd