Complex 5zc9
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.00 |
| System mass | 49.26 kDa |
| Deposition year | 2018 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | N/A |
| RCSB PDB Entry | 5zc9 |
| Reference | Iwasaki Shintaro, Iwasaki Wakana, Takahashi Mari, Sakamoto Ayako, Watanabe Chiduru, Shichino Yuichi, Floor Stephen N., Fujiwara Koichi, Mito Mari, Dodo Kosuke, Sodeoka Mikiko, Imataka Hiroaki, Honma Teruki, Fukuzawa Kaori, Ito Takuhiro, Ingolia Nicholas T.. 2019. The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA Molecular Cell |
| Equivalence Class |
NR_all_14757.3
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | RCG |
| Residue | . / 600 |
| Chain | E / B |
| Non-redundant | True |
| Interacting RNA chains | B/B |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | B/B: synthetic construct |
| RNA family global | synthetic construct |
| Volume | 145.09 Å3 |
| Hydrophobicity | 1.068 |
| Hydrophilicity | 0.445 |
| Buriedness | 0.554 |
| Don/acc character | 1.790 |
| SiteScore | 0.824 |
| D Score | 0.878 |
| Kd | — |