Complex 5wis
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.70 |
| System mass | 4572.63 kDa |
| Deposition year | 2017 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Tequatrovirus |
| RCSB PDB Entry | 5wis |
| Reference | Almutairi Mashal M., Svetlov Maxim S., Hansen Douglas A., Khabibullina Nelli F., Klepacki Dorota, Kang Han-Young, Sherman David H., Vázquez-Laslop Nora, Polikanov Yury S., Mankin Alexander S.. 2017. Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins Nucleic Acids Research |
| Equivalence Class |
NR_all_97519.80
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | MT9 |
| Residue | . / 4113 |
| Chain | CUA / 1A |
| Non-redundant | True |
| Interacting RNA chains | A/1A |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/1A: rRNA |
| RNA family global | rRNA |
| Volume | 433.55 Å3 |
| Hydrophobicity | 0.191 |
| Hydrophilicity | 1.806 |
| Buriedness | 0.772 |
| Don/acc character | 0.541 |
| SiteScore | 1.199 |
| D Score | 0.814 |
| Kd | — |
| Compound | MT9 |
| Residue | . / 3897 |
| Chain | EVC / 2A |
| Non-redundant | True |
| Interacting RNA chains | EB/2A |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | EB/2A: rRNA |
| RNA family global | rRNA |
| Volume | 107.36 Å3 |
| Hydrophobicity | 0.379 |
| Hydrophilicity | 0.918 |
| Buriedness | 0.599 |
| Don/acc character | 1.301 |
| SiteScore | 0.722 |
| D Score | 0.698 |
| Kd | — |