Complex 5tbw
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 3.00 |
| System mass | 6294.77 kDa |
| Deposition year | 2016 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Saccharomyces |
| RCSB PDB Entry | 5tbw |
| Reference | Könst Zef A., Szklarski Anne R., Pellegrino Simone, Michalak Sharon E., Meyer Mélanie, Zanette Camila, Cencic Regina, Nam Sangkil, Voora Vamsee K., Horne David A., Pelletier Jerry, Mobley David L., Yusupova Gulnara, Yusupov Marat, Vanderwal Christopher D.. 2017. Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides Nature Chemistry |
| Equivalence Class |
NR_all_90506.85,
NR_all_03510.74
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | 7AL |
| Residue | . / 4210 |
| Chain | GKA / 1 |
| Non-redundant | True |
| Interacting RNA chains | A/1 |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | A/1: rRNA |
| RNA family global | rRNA |
| Volume | 357.06 Å3 |
| Hydrophobicity | 0.221 |
| Hydrophilicity | 1.150 |
| Buriedness | 0.664 |
| Don/acc character | 0.770 |
| SiteScore | 0.977 |
| D Score | 0.963 |
| Kd | — |
| Compound | 7AL |
| Residue | . / 4246 |
| Chain | EVB / AR |
| Non-redundant | True |
| Interacting RNA chains | TA/AR |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | TA/AR: rRNA |
| RNA family global | rRNA |
| Volume | 353.63 Å3 |
| Hydrophobicity | 0.071 |
| Hydrophilicity | 1.431 |
| Buriedness | 0.645 |
| Don/acc character | 0.575 |
| SiteScore | 0.965 |
| D Score | 0.861 |
| Kd | — |