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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 5m1j

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.30
System mass 3195.27 kDa
Deposition year 2016
Molecule type RNA/Protein
# RNA entities 1
Organism Saccharomyces
RCSB PDB Entry 5m1j
Reference Hilal Tarek, Yamamoto Hiroshi, Loerke Justus, Bürger Jörg, Mielke Thorsten, Spahn Christian M.T.. 2016. Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution Nature Communications
Equivalence Class NR_all_90506.85
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GNP
Residue . / 701
Chain WQA / A6
Non-redundant True
Interacting RNA chains JA/14
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains JA/14: rRNA
RNA family global rRNA
Volume 389.99 Å3
Hydrophobicity 0.189
Hydrophilicity 1.819
Buriedness 0.747
Don/acc character 0.459
SiteScore 1.033
D Score 0.795
Kd