Complex 5iwa
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 3.50 |
| System mass | 769.66 kDa |
| Deposition year | 2016 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Thermus |
| RCSB PDB Entry | 5iwa |
| Reference | Fabbretti Attilio, Schedlbauer Andreas, Brandi Letizia, Kaminishi Tatsuya, Giuliodori Anna Maria, Garofalo Raffaella, Ochoa-Lizarralde Borja, Takemoto Chie, Yokoyama Shigeyuki, Connell Sean R., Gualerzi Claudio O., Fucini Paola. 2016. Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding Proceedings of the National Academy of Sciences |
| Equivalence Class |
NR_all_65795.87
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | 6EK |
| Residue | . / 201 |
| Chain | AA / M |
| Non-redundant | True |
| Interacting RNA chains | U/A |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | U/A: rRNA |
| RNA family global | rRNA |
| Volume | 122.79 Å3 |
| Hydrophobicity | 0.092 |
| Hydrophilicity | 0.583 |
| Buriedness | 0.428 |
| Don/acc character | 2.177 |
| SiteScore | 1.057 |
| D Score | 1.007 |
| Kd | — |