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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 5ib8

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.13
System mass 4534.39 kDa
Deposition year 2016
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 5ib8
Reference Rozov Alexey, Westhof Eric, Yusupov Marat, Yusupova Gulnara. 2016. The ribosome prohibits the G•U wobble geometry at the first position of the codon–anticodon helix Nucleic Acids Research
Equivalence Class NR_all_97519.80
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPE
Residue . / 3458
Chain XBB / 14
Non-redundant True
Interacting RNA chains CC/14
RNA environment detailled ion
RNA environment global RNA
RNA family chains CC/14: rRNA
RNA family global rRNA
Volume 186.25 Å3
Hydrophobicity 0.044
Hydrophilicity 1.584
Buriedness 0.665
Don/acc character 1.101
SiteScore 1.021
D Score 0.686
Kd