HARIBOSS logo

HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 5fcj

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.10
System mass 6565.29 kDa
Deposition year 2015
Molecule type RNA/Protein
# RNA entities 1
Organism Saccharomyces
RCSB PDB Entry 5fcj
Reference Mailliot Justine, Garreau de Loubresse Nicolas, Yusupova Gulnara, Meskauskas Arturas, Dinman Jonathan D., Yusupov Marat. 2016. Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency Journal of Molecular Biology
Equivalence Class NR_all_90506.85
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ANM
Residue . / 3401
Chain FO / 1
Non-redundant True
Interacting RNA chains JA/1
RNA environment detailled ion
RNA environment global RNA
RNA family chains JA/1: rRNA
RNA family global rRNA
Volume 647.24 Å3
Hydrophobicity 0.098
Hydrophilicity 1.754
Buriedness 0.776
Don/acc character 0.713
SiteScore 1.202
D Score 0.834
Kd